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KMID : 1189420090220020082
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Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2009 Volume.22 No. 2 p.82 ~ p.91
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Experimental studies about the inhibitory effect on tyrosinase and elastase activities by various herb medicines
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Jung Jae-Hoon
Kim Kyung-Jun
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Abstract
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Objectives : The purpose of this study is to investigate whitening effects and anti-wrinkle effects of a few 80% ethanol extracted herbal medicines.
Methods : In the first study, a few 80% ethanol extracted herbal medicines were screened for their inhibitory activities against the tyrosinase. In the second study, a few 80% ethanol extracted herbal medicines were screened for their inhibitory activities against elastase.
Results : 1. We showed 28%, 27% and 19% inhibitions of mushroom tyrosinase at 500 ㎍/㎖ concentration of ASR, AIF and ABR extracts and they were showed higher anti-tyrosinase activity than arbutin’s. We also could observe that the decreased mushroom tyrosinase activities in RR, CML, LR, AGR and TH extracts. 2. RR, AF and ABR (final concentrstion 1 ㎎/㎖) were appeared 60%, 98%, 83% of inhibitions of elastase activity, and they were showed higher anti-elastase activity than that of ursolic acid. We also could observe that the decreased elastase activities in AIF, AR, LR and CML extracts.
Conclusions : These results suggest that ASR, AIF and ABR extracts contribute to the anti-melanin activities and represent potential sources of whitening agent, and RR, AF and ABR extracts contribute to the anti-elastase activities and represent potential sources of anti-wrinkle agent. These results suggest that some herbal medicines could be strong potential sources of inhibition about anti-aging and whitening effects for the skin.
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KEYWORD
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tyrosinase, melanin, L-DOPA(3, 4-dihydroxyphenylalanin), Elastin, Elastase
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